| Date | Opponent | Location | Time | TV | Result | Record | |
|---|---|---|---|---|---|---|---|
 | 09/03/2011 | vs. Tennessee Tech | Kinnick Stadium, Iowa City, IA | 11:00 AM | BTN | W 34-7 | 1-0 (0-0) |
 | 09/10/2011 | at Iowa State | Jack Trice Stadium, Ames, IA | 11:00 AM | FSN | L 41-44 (3OT) | 1-1 (0-0) |
 | 09/17/2011 | vs. Pittsburgh | Kinnick Stadium, Iowa City, IA | 11:00 AM | ESPN2 | W 31-27 | 2-1 (0-0) |
 | 09/24/2011 | vs. Louisiana-Monroe | Kinnick Stadium, Iowa City, IA | 11:00 AM | BTN | W 45-17 | 3-1 (0-0) |
 | 10/08/2011 | at Penn State | Beaver Stadium, University Park, PA | 2:30 PM | ABC/ESPN | L 3-13 | 3-2 (0-1) |
 | 10/15/2011 | vs. Northwestern | Kinnick Stadium, Iowa City, IA | 6:00 PM | BTN | W 41-31 | 4-2 (1-1) |
 | 10/22/2011 | vs. Indiana | Kinnick Stadium, Iowa City, IA | 11:00 AM | BTN | W 45-24 | 5-2 (2-1) |
 | 10/29/2011 | at Minnesota | TCF Bank Stadium, Minneapolis, MN | - | - | L 21-22 | 4-3 (2-2) |
 | 11/05/2011 | vs. Michigan | Kinnick Stadium, Iowa City, IA | - | - | W 24-16 | 5-3 (3-2) |
 | 11/12/2011 | vs. Michigan State | Kinnick Stadium, Iowa City, IA | - | - | L 21-37 | 6-4 (3-3) |
 | 11/19/2011 | at Purdue | Ross-Ade Stadium, West Lafayette, IN | - | - | W 31-21 | 7-4 (4-3) |
 | 11/25/2011 | at Nebraska | Memorial Stadium, Lincoln, NE | 11:00 AM | ABC | L 7-20 | 7-5 (4-4) |
| 12/30/2011 | vs Oklahoma | Insight Bowl | - | - | L 14-31 | 7-6 (4-4) |